Description

ANTIFUNGAL- ANTIFUNGAL Manufacturers and Suppliers

Infections by fungi have increased in recent years, mainly because of advances in surgery and treatment for cancer. More patients are at risk due to solid organ transplants or having HIV/AIDS. Broad-spectrum antimicrobial therapy is also increasing the number of vulnerable people globally.

How do they work?

Antifungal drugs used to treat fungal infections are selective against fungus because they have a greater affinity for their human counterparts. They work by inhibiting the synthesis of ergosterol in fungi primarily through the inhibition of cytochrome P450 enzymes.

Some Major Antifungal drugs are.

AMPHOTERICIN B

Amphotericin A and B are antifungal antibiotics produced by Streptomyces nooses. Amphotericin B kills fungi by targeting the ergosterol in their cell membranes.

The intravenous injection of amphotericin B elicits a drug level in the bloodstream that is 90% bound by serum proteins and excreted through urine.

 FLUCYTOSINE.

Flu cytosine is a drug that inhibits DNA and RNA synthesis in fungi.

It is an oral drug used in AIDS patients with compromised renal function.

AZOLES

Azole drugs inhibit the growth of fungi by reducing their ability to synthesize ergosterol, which is necessary for fungal cell membranes.

Azoles are a type of drug that can be either imidazole or diazole, depending on the number of nitrogen atoms in the five-membered used only in topical therapy

MNYSTATIN.

NY statin is a fungus killer that has little toxicity.

It is a polygene macrolide that is only used topically.

Adverse effects.

Infusion-Related Toxicity.

When starting therapy, many clinicians administer a test dose of 1 mg intravenously to gauge the severity of the reaction. This can serve as a guide to an initial dosing regimen and premedication strategy that may prove helpful in preventing infusion-related reactions from occurring again during future treatments.

Cumulative Toxicity.

Renal damage is the most significant toxic reaction. Renal impairment occurs in nearly all patients treated with clinically significant doses of amphotericin, and it can be serious enough

to necessitate dialysis. A reversible component associated with decreased renal perfusion represents a form of prerenal nephrotoxicity while an irreversible component results from a tubular injury that leads to dysfunction. The irreversible form usually happens when there are high concentrations of dosing errors