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What is penicillin
Penicillin was discovered when Alexander Fleming noticed how bread mold killed bacteria in a petri dish. Teeming with bacteria, the unpleasant-looking green mold appeared to produce a chemical that could kill disease-causing microbes. Penicillin is processed from fungus cultures and is often used to treat bacterial infections or diseases such as anthrax or strep throat.
How does it work?
Penicillin is a type of antibiotic that works by preventing the elongation process in bacteria. This is because after being split up, peptidoglycan binds itself to penicillin-binding protein 1A (PBP1a) which interrupts cell wall synthesis and growth.
When should you take penicillin?
Penicillin is a drug of choice for infections caused by streptococci, meningococcal, some enterococcus s, penicillin-susceptible pneumococcus ci, non-β -lactamase producing staphylococcus i, and certain other spirochetes. High dose penciling can also be used for treating syphilis
Penicillin side effects
The penicillin’s are generally well-tolerated, but this may encourage inappropriate use. Most of the serious adverse effects
are due to hypersensitivity and a history of a penicillin reaction is unreliable because only about 5–8% have had one. Less than 1% will experience anaphylaxis when receiving it again after taking it without incident before which is why they recommend skin prick testing or allergy blood tests for those considering using them as first-line treatment against strep throat in order to avoid future reactions that could be life-threatening if not caught early enough by doctors at their discretion who carry epinephrine around with them during office hours just in case someone has either experienced past incidents themselves or know from past experiences where patients come into the clinic complaining.
Dosage instructions for penicillin.
Acid-stable penicillin’s like dicloxacillin, ampicillin, and amoxicillin is usually well absorbed after oral administration. They produce serum concentrations in the range of 4–8 mcg/mL following a 500mg dose.
Benzedrine and procaine penicillin is formulated to delay absorption, resulting in prolonged blood and tissue concentrations. A single intramuscular injection of 1.2 million units of benzathine penicillin maintains serum levels above 0.02 mcg/mL for 10 days, sufficient to treat β-hemolytic streptococcal infection after 3 weeks, levels still exceed 0 .003mcg/ml which is enough to prevent β hemolytic strep infections a 600 000 unit dose precise peak concentrations at
1–2 mcg/mL clinically useful when administrated over 24 hours.